Animal models for the study of human disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease the first section addresses how to locate resources animal alternatives animal ethics and related issues much needed information for researchers across the biological sciences and biomedicinethe next sections of the work offers models for disease oriented topics including cardiac and pulmonary diseases aging . Atherosclerosis is a chronic inflammatory disease that is an underlying basis for most cardiovascular diseases in humans animal models are indispensable for studying the molecular mechanisms that promote atherogenesis and testing therapeutic strategies both large and small animal models have been used to study atherogenesis although nonhuman primates come closest to modeling human disease there are significant limitations to the use of these species rabbits and pigs have a number of . Animal models for the study of human disease amazonde conn p michael fremdsprachige bucher wahlen sie ihre cookie einstellungen wir verwenden cookies und ahnliche tools um ihr einkaufserlebnis zu verbessern um unsere dienste anzubieten um zu verstehen wie die kunden unsere dienste nutzen damit wir verbesserungen vornehmen konnen und um werbung anzuzeigen. This chapter provides an introduction to the concept of laboratory animal models focusing on a general classification of animal models for the study of human diseases animal models can be grouped into one of the following five categories 1 induced experimental models 2 spontaneous genetic mutant models 3 genetically modified models 4 negative models and 5 orphan models this is followed by a discussion of how knowledge concerning human biology and pathobiology can be